Controllable CAR T cells for the treatment of liquid and solid tumors
Dynamic Cell Therapies is developing controllable CAR T cells to address difficult-to-treat cancers. Our platform technology of dynamic control of engineered T cells will improve the safety, efficacy, and durability of CAR T cell therapies. This system will have immediate applications in hematological cancers, with future approaches in solid tumors and autoimmune diseases.
Dynamic Controllable CAR T Cell System
The activity of the controllable CAR T cell system can be titrated by dosing the small molecule-antibody conjugate to maximize tumor cell killing while minimizing toxicity.
Drag the slider from left to right to increase the amount of small-molecule antibody conjugates.
How it Works
By recognizing small molecules, CAR T cells do not cross react with normal tissue.
CAR T cell activity is proportional to the number of small molecule-antibody conjugates.
The small molecule-antibody conjugates bind to a specific tumor cell antigen.
When small molecule-antibody conjugates bind to tumor cells, CAR T cells recognize the small molecules selectively associated with tumors.
CAR T cells release perforins which punch holes in the tumor cell membrane resulting in cell death.
Activated CAR T cells release cytokines to recruit and stimulate the body’s natural immune cells to participate in the attack against cancer cells.
If the tumor cells evade recognition, a new small molecule antibody conjugate can be administered targeting a different antigen. Additional leukapheresis is not required.
Multiple different antibodies targeting various antigens coupled to the same small molecule can be dosed together. Antibodies against different tumor antigens can be chosen to maximize on-target on-tumor CAR T cell activity and minimize on-target off-tumor toxicities. For example, one antibody can possess specific on-target off-tumor reactivity, and a second antibody can be chosen for a different set of on-target off-tumor properties. In this way, the physician can maximize efficacy and limit toxicity.